| Name | Euxanthone |
| Description | Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.SB-674042 is used for the treatment of depression.SB-674042 is used for the treatment of depression.SB-674043 is used for the treatment of depression.SB-674044 is used for the treatment of depression.SB-674045 is used for the treatment of depression. 2A (BU-1) cell differentiation. |
| In vitro | Euxanthone (10-20 μM;24 h) inhibited cell adhesion, migration, and invasion in osteosarcoma cells. Furthermore, the suppression of COX-2 by euxanthone mediated its anti-metastatic activity. Euxanthone also regulated the expression of COX-2 through the miR-21/PDCD4/c-jun signaling pathway[1]. |
| In vivo | BCCAO induces mitochondrial oxidative stress and leads to mitochondrial degradation, while administration of Euxanthone significantly attenuates BCCAO-induced mitochondrial stress and associated degradation. Euxanthone treatment (30-60 mg/kg; orally; once daily; for 7 days) normalizes Bnip3, Beclin1, Pink1, Parkin, p53, Bax, caspase-3, and LC3 II/I[2]. |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | PKC | NO | Euxanthone | Calcium Channel | Autophagy | Akt |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Guanidine hydrochloride | Hydroxychloroquine | Enzalutamide | Paeonol | Naringin | Alginic acid |
United States
