| Name | EWP 815 |
| Description | EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase activity [1] [2]. |
| In vitro | EWP 815 (6, 8 μM; 10 min) inhibits dephosphorylation of [3H]Ins(1,4,5)P3 5-phosphatase in particulate and soluble fractions with IC50s of 6 μM and 8 μM, respectively.[1]
EWP 815 (30 μM; 1 h) exerts higher inhibition on Ins(1,4)P2 phosphatase rather than Ins(1,4,5)P3 5-phosphatase with the mean [3H]Ins(1,4)P2/mean [3H]InsP recovery ratio of 2.6.[1]
EWP 815 (3-300 μM; 30 min) suppresses thyrotropin-releasing hormone (TRH)-stimulated (100 nM) inositol phospholipid production by 30% (100 μM) and 1.8% (300 μM), respectively, without affecting Ins(1,4,5)P3 binding.[1] |
| In vivo | EWP 815 (50 mg/kg; i.p.; administered 30 minutes before euthanasia) inhibits dopamine β-hydroxylase activity in mice, reducing the amount of 3 H-α-Me-NA by 12%.[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 1 mg/mL (2.85 mM), Sonication is recommended.
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| Keywords | Phosphatase | Dopamine β-hydroxylase |
| Inhibitors Related | β-Glycerophosphate disodium salt pentahydrate | Casein | Hexane-1,6-diol | 4-Chloro-L-phenylalanine | Ketoconazole | Idoxuridine | Cyclosporine | Tartaric acid disodium dihydrate | Stearic acid | L-Ascorbic acid 2-phosphate magnesium | Cyclosporin A | β-Glycerophosphate disodium salt hydrate |
| Related Compound Libraries | Glycometabolism Compound Library | Bioactive Compound Library | Multi-Target Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Phosphatase Inhibitor Library |
United States
