| Name | (E/Z)-BCI |
| Description | (E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS production in macrophage cells by activating the Nrf2 signaling axis and inhibiting the NF-κB pathway. |
| In vitro | (E/Z)-BCI hydrochloride (2-10 μM; 72 hours) significantly reduces cell viability in a time and dose-dependent manner in gastric epithelial cell GES1, GC cell lines, and AGS cell lines. Additionally, (E/Z)-BCI hydrochloride (0.5-4 μM; 24 hours) significantly inhibits DUSP6 expression in LPS-activated macrophages, while also inhibiting cell proliferation, migration, and invasion in a receptor-independent manner, enhancing Cisplatin (CDDP) cytotoxicity, and promoting apoptosis in GC cells. Moreover, (E/Z)-BCI hydrochloride (0.5-2 μM; 24 hours) significantly suppresses IL-1β, TNF-α, and IL-6 mRNA expression in LPS-activated macrophages, decreases ROS production, and activates the Nrf2 pathway. |
| In vivo | (E/Z)-BCI hydrochloride treatment enhances cisplatin efficacy in PDX models. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 20 mg/mL (63.01 mM), Sonication is recommended.
DMSO : 50 mg/mL (157.52 mM), Sonication is recommended.
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| Keywords | ROS | Phosphatase | NSC-150117 | NSC150117 | Nrf2 | NF-κB | LPS | Inhibitor | inhibit | gastric cancer | ERK | DUSP6 | death | Apoptosis | anti-inflammatory | (E/Z)-BCI | (E/Z)BCI | (E/Z) BCI |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Apoptosis Compound Library | NF-κB Signaling Compound Library | Glycometabolism Compound Library | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Phosphatase Inhibitor Library |
United States
