| Name | (E/Z)-SIB-1893 |
| Description | (E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893. (E)-SIB-1893 is a selective, noncompetitive mGluR5 antagonist with anticonvulsant activity . |
| In vitro | We investigated the role of mGluR5 in acute NMDA and glutamate-mediated neurodegeneration in cultured rat cortical cells using the mGluR5 antagonists SIB-1893 (20 or 200 μM; rat cortical cells) and found that they provide significant protection.[4] |
| In vivo | (E/Z)-SIB-1893 (10, 20, and 30 mg/kg; i.p.; 0-180 min) considerably lowered the body temperature in animals at 90, 120, and 180 min after its systemic injection of 30 mg/kg. In contrast, the drug at 10 and 20 mg/kg remained without effect on the body temperature in rats. Based on our preclinical study, one can conclude that (E/Z)-SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner.[1]
SIB 1893 (10 and 20 mg/kg; mice; i.p.) did not affect the protective action of valproate, ethosuximide, phenobarbital, and clonazepam in this test. The combined treatment of SIB 1893 with conventional antiepileptic drugs did not lead to motor impairment. Long-term memory disturbances were observed only in the case of the combination of SIB 1893 with phenobarbital.[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 90 mg/mL (460.92 mM), Sonication is recommended.
10% DMSO+90% Saline : 3.3 mg/mL (16.9 mM), Sonication is recommended.
|
| Keywords | SIB-1893 | SIB1893 | mGluR | (E/Z)-SIB-1893 | (E/Z)-SIB1893 | (E/Z)-SIB 1893 |
| Inhibitors Related | S-Sulfo-L-cysteine sodium salt | IDRA-21 | Urethane | Decanoic Acid | DCB | L-Cysteic acid monohydrate | Evans blue | L-Glutamine | Direct Blue 1 | L-Glutamic acid monosodium salt | Memantine hydrochloride | O-Phospho-L-serine |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Glutamine Metabolism Compound Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Neuroprotective Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
United States
