| Name | Fanotaprim |
| Description | Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor, suppressing the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM, a hDHFR IC50 of 308 ± 71 nM, and a hDHFR to TgDHFR selectivity ratio of 196. |
| In vitro | Fanotaprim exhibits parasiticidal and antiproliferative effects with EC50s of 13 and 7300 nM against the type I RH strain of T. gondii and MCF-7 cells, respectively[1]. It also inhibits the growth of T. gondii strains in vitro with EC50s ranging from 7.6 to 29.8 nM (GT1, ME49, CTG, RUB, and VAND)[1]. |
| In vivo | Fanotaprim (1-10 mg/kg; p.o.; daily; beginning on day 1 through day 7) is highly effective in controlling acute infection by highly virulent strains of T. gondii in the murine model[1]. In mice, Fanotaprim (1 mg/kg; i.v.) shows CL, Vd, and t1/2 values of 10.6 mL/min/kg, 1.14 L/kg, and 3.9 hours, respectively[1]. When administered orally at 0.83 mg/kg, Fanotaprim exhibits F, Cmax, Tmax, and AUC0-last values of 47.3%, 178 ng/mL, 0.05 hours, and 750 ng h/mL, respectively[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 25 mg/mL (66.06 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.28 mM), Sonication is recommended.
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| Keywords | VYR-006 | VYR006 | VYR 006 | toxoplasmosis | survival | reductase | mice | Inhibitor | inhibit | Fanotaprim | dhydrofolate | DHFR | CD-1 | Antifolate |
| Inhibitors Related | Pemetrexed | Methotrexate | Epiroprim | Urea | Folinic acid | Methotrexate disodium | Trimethoprim | Folinic acid calcium | Gentamicin sulfate | Folinic Acid Calcium Salt Pentahydrate | Trimethoprim lactate | Sulfameter |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Anti-Parasitic Compound Library | Bioactive Compound Library | ReFRAME Related Library | Inhibitor Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Anti-Cancer Compound Library | Anti-Infection Compound Library |
United States
