| Name | FDW028 |
| Description | FDW028 is a selective and potent fucosyltransferase 8 (FUT8) inhibitor with anti-tumor activity that drives B7-H3 lysosomal degradation via defucosylation and CMA pathways. FUT8 can be used to study metastatic colorectal cancer (mCRC). |
| In vitro | METHODS: FDW028 (0.316-316μM, 72 hours) was used to treat SW480 and HCT-8 cells, and cell viability was detected with or without FUT8 knockdown.
RESULTS:FDW028 exhibited potent antitumor capabilities in terms of cell proliferation, with half-maximal inhibitory concentration (IC50) values of 5.95 µM and 23.78 µM in SW480 and HCT-8 cells, respectively. [1]
METHODS: SW480 and HCT-8 cells were treated with FDW028 (50 μM, 72 hours) for Transwell and wound healing assays.
RESULTS:FDW028 significantly inhibited the migration of SW480 and HCT-8 cells. [1] |
| In vivo | METHODS: FDW028 (10, 20 mg/kg, intravenous injection, 4-6 weeks) was administered to athymic male SCID tumor xenograft mice to explore the effect of FDW028 on CRC growth.
RESULTS:FDW028 exerted potent antitumor activity against CRC and significantly inhibited the growth of mouse tumors. [1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (205.94 mM), Sonication is recommended.
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| Keywords | FUT8 | FDW028 | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Hydroxychloroquine | Ethyl linoleate | Paeonol | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | PI3K-AKT-mTOR Compound Library | Bioactive Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
