| Name | Ferroquine |
| Description | Ferroquine (Ferrochloroquine) is a ferrocenyl analogue of Chloroquine with antimalarial activity. Ferroquine induces oxidative stress and the subsequent destruction of the membrane, resulting in parasiticidal effect on Plasmodium. |
| In vitro | All newly transformed schistosomula (NTS) exposed to 33.3 µM hydroxyl-ferroquine (FQ-OH), Ferroquine (FQ), and Ruthenoquine (RQ) displays strongly decrease liabilities, after 24 hours post-incubation. All NTS exposed to 33.3 µM RQ have died, while Ferroquine and FQ-OH treated worms are strongly affected but still alive, after 72 hours post-incubation [1]. |
| In vivo | Ferroquine (200 and 800 mg/kg; mice ) treatment, displays low total worm burden reductions of 19.4% and 35.6%. One of the mice treated with 800 mg/kg Ferroquine died within 24 hours post-treatment. No activity is observed treating mice with Ruthenoquine at 200 mg/kg. Hence, modification of Chloroquine (CQ) by a ferrocenyl or ruthenocenyl fragment does not increase the antischistosomal properties of CQ. A total worm burden reduction of 17.3% is observed following treatment with hydroxyl-ferroquine. Furthermore, in one of the hydroxyl-ferroquine treated mice many dead worms are recovered and a hepatic shift (i.e. worms migrating to the liver) observed. Hence, Ferroquine and hydroxyl-ferroquine show weak antischistosomal activity in vivo[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 7.5 mg/mL (17.29 mM), Sonication is recommended.
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| Keywords | SSR-97193 | SSR 97193 | Ferroquine | antimalarial |
| Inhibitors Related | Flubendazole | Gum arabic | Kojic acid | Urethane | Hydroxychloroquine | Metronidazole | Avermectin B1a | 2-Amino-2-methyl-1-propanol | Doxycycline | Fenpyroximate | Methylene Blue trihydrate | Coumaran |
| Related Compound Libraries | Anti-Parasitic Compound Library | Failed Clinical Trials Compound Library | Bioactive Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
United States
