| Name | FGI-106 tetrahydrochloride |
| Description | FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective concentrations (EC50s) of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, it effectively inhibits non-hemorrhagic fever viruses, notably HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively, indicating its broad-spectrum antiviral potential. |
| In vitro | In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM. |
| In vivo | FGI-106??treatment decreases mortality from Zaire EBOV in a dose-dependent manner. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 7.5 mg/mL (12.41 mM), Sonication is recommended.
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| Keywords | VirusProtease | Virus Protease | tetrahydrochloride | Rift Valley virus | replication | pathogens | lethal | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | Human immunodeficiency virus | HIVProtease | HIV-1 | HIV Protease | HIV | Hepatitis C virus | hemorrhagic | HCVProtease | HCV Protease | HCV | FGI-106 tetrahydrochloride | FGI106 tetrahydrochloride | FGI-106 | FGI106 | FGI 106 Tetrahydrochloride | FGI 106 | fever | EBOV | Ebola virus | Ebola | Dengue Fever virus | broad-spectrum | antiviral |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Emtricitabine | Phenytoin sodium | Lamivudine | Penicillin G potassium | Curcumin | (E)-3-(p-Tolyl)acrylaldehyde | Thymidine | Decanedioic acid | Dextran sulfate sodium salt (MW 5000) | β-Cyclodextrin |
| Related Compound Libraries | Bioactive Compound Library | Multi-Target Compound Library | Anti-Viral Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
United States
