| Name | Fingolimod |
| Description | Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells). |
| Cell Research | Sciatic nerve crush was performed in wildtype C57BL/6, in immunodeficient Rag1 (-/-) and Foxn1 (-/-) mice.?Analyses were based on walking track analysis and electrophysiology, histology, and cAMP formation.?Quantification of different LPA species was performed by liquid chromatography coupled to tandem mass spectrometry.?Furthermore, functional consequences of autotaxin inhibition by the specific inhibitor PF-8380 and the impact of fingolimod on early cytokine release in the injured sciatic nerve were investigated[1]. |
| In vitro | Fingolimod has been reported to reduce LPA synthesis via inhibition of the lysophospholipase autotaxin.?Fingolimod treatment correlates with a significant elevation of axonal cAMP, a crucial factor for axonal outgrowth.?Additionally, Fingolimod significantly reduces LPA levels in the injured nerve.?PF-8380 treatment correlates with improved myelin thickness[1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Methanol : 30 mg/mL (97.57 mM), Sonication is recommended.
Ethanol : 7.69 mg/mL (25.01 mM), Sonication is recommended.
DMSO : 1 mg/mL (3.25 mM), Sonication is recommended.
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| Keywords | S1PReceptor | S1P Receptor | S1P | PAK | p21 activated kinases | Lysophospholipid Receptor | LPLReceptor | LPL Receptor | LPL | Inhibitor | inhibit | FTY720 | FTY 720 | Fingolimod |
| Inhibitors Related | LX-2931 | Tyloxapol | Sphingosine-1-phosphate | ASP-4058 | CAY10444 | Ki16198 | Siponimod | 5-Aminosalicylic Acid | CYM5181 | Poloxamer 407 | S1PR1 modulator 1 | MP-A08 |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | GPCR Compound Library | Anti-Cancer Drug Library |
United States
