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ChemicalBook Product Catalog FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)

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FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium) NEW

$ 2049.00 /1mg

Min. Order
Purity
Cas No
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP2Y

United States

United States

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Chemical Properties

Product Name	FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)
CAS No
EC-No
Min. Order
Purity
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)
Description	FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium) is a fluorescein isothiocyanate (FITC)-tagged monomeric peptide of amyloid beta 1-42, which plays a critical role in the pathogenesis of Alzheimer’s disease, making FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium) a valuable tool for mechanistic studies, drug screening, and biomolecular investigations related to neurodegenerative processes.
In vitro	β‑Amyloid aggregation protocol (recommended procedure, adjust according to downstream applications). Monomer preparation: 1. Dissolve solid Aβpeptide in ice‑cold hexafluoro‑2‑propanol (HFIP). Incubate the peptide solution at room temperature (RT)for at least 1 h to ensure complete monomerization and conformational randomization. 2. Obliterate HFIP under vacuum. Store the resulting peptide film at −20 °Cor −80 °C. Oligomer preparation: 3. Add anhydrous DMSO to the peptide film to prepare a 5 mM stock solution; mix thoroughly by vortexing. Dilute to the desired concentration with ice‑cold PBS or serum‑free, phenol‑red‑free DMEM/F12. 4. Incubate the diluted solution at 4–8 °Cfor 24–48 h. Then centrifuge at 4–8 °C and 14,000 × g for 10 min; soluble oligomers are in the supernatant. Dilute the supernatant 10–200×immediately before use. Fibril preparation: 5. Add anhydrous DMSO to the peptide film to prepare a 5 mM stock solution; vortex to mix. Dilute to the required concentration with 10 mM HCl. 6. Incubate the diluted solution at 37 °Cfor 24–48 h to obtain Aβ42 fibrils. Notes: If insoluble material is present after step 1, extend HFIP treatment (e.g., overnight incubation), vortex, or apply brief sonication; if residues persist, remove by centrifugation or filtration. Different aggregated forms of Aβ are solution‑labile; prepare fresh whenever possible. For longer‑term storage, keep the peptide as a film at −20 °C or −80 °C.
Storage	Shipping with blue ice/Shipping at ambient temperature.
Inhibitors Related	Benzenesulfonamide \| Deferoxamine Mesylate \| Cromolyn sodium \| HEPPS \| Phytic acid sodium salt \| Rutin \| Resveratrol \| 10-Undecenoic acid \| 2,4-Di-tert-butylphenol \| Chlorzoxazone \| Methyl tridecanoate \| Glimepiride

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