| Name | Fludrocortisone |
| Description | Fludrocortisone (Florinef) is a synthetic corticosteroid with moderate glucocorticoid potency and greater mineralocorticoid potency. Fludrocortisone is in research use for the treatment of hypotension.[3] |
| In vitro | METHODS: MIO-M1 cells were selected to study the anti-inflammatory effects of Fludrocortisone （Florinef） under IL-1β or TNF-α stimulation. Fludrocortisone was added to the culture medium at a concentration of 1 μg/μl, and 1 ng/μl of IL-1β or TNF-α was added at the same time.
RESULTS Fludrocortisone reduced the expression of CCL2, IL-6, and IL-8 to baseline levels after TNF-α stimulation. [2] |
| In vivo | METHODS: Wistar rats were treated intravenously with Fludrocortisone （Florinef） (5 and 20 μg/kg). The effects of a single dose of fludrocortisone on systolic blood pressure in normal and endotoxemic rats were evaluated until 2 h after treatment injection and in vitro vasoconstriction to phenylephrine in mesenteric artery rings 3 h after treatment.
RESULTS Fludrocortisone increased systolic blood pressure (P < 0.001), but more in endotoxemic than in normal animals. Fludrocortisone significantly improved the contractile response to phenylephrine (P = 0.039 and P = 0.007, respectively). [1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 55.5 mg/mL (145.88 mM), Sonication is recommended.
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| Keywords | Mineralocorticoid Receptor | Fludrocortisone | 9alpha-fluorohydrocortisone | 9alpha-fluorocortisol | 9alpha-Fluorcortisol | 9alpha-Fludrocortisone | 9a-fluorohydrocortisone | 9a-fluorocortisol | 9a-Fluorcortisol | 9a-Fludrocortisone |
| Inhibitors Related | Phenytoin sodium | Procaine | Mifepristone | Lidocaine | Valproic Acid | Dexamethasone acetate | L-Aspartic aicd sodium | Lidocaine hydrochloride | Mebeverine hydrochloride | Dexamethasone | Dexamethasone Phosphate disodium | Prednisone acetate |
| Related Compound Libraries | Nuclear Receptor Compound Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Pediatric Drug Library | Sodium Channel Targeted Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Orally Active Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Bioactive Lipid Compound Library | Human Metabolite Library |
United States
