| Name | Flunarizine |
| Description | Flunarizine is an orally administered peripheral vasodilator, acting as a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist, exhibiting anti-migraine activity. |
| In vitro | In cultured rat cortical neurons, Flunarizine blocks sodium current (INa) and calcium current (ICa), with half-maximal inhibitory concentrations (IC50) of 0.94 μM and 1.77 μM, respectively [2].
Flunarizine (concentrations 10 μM, 30 μM; exposure time 24 hours) exhibits cytotoxic effects on chromaffin cells [4].
Within the concentration range of 3-10 μM, Flunarizine demonstrates significant cytoprotective effects on chromaffin cells [4]. |
| In vivo | In a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model, preventive administration of Flunarizine (30 mg/kg, intraperitoneal injection) significantly inhibited LPS-induced cell infiltration, protein leakage, and inflammatory cytokine release. Therapeutic administration of flunarizine (30 mg/kg, intraperitoneal injection) also suppressed pulmonary inflammation, but its efficacy was weaker than that of preventive administration [5]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (197.78 mM), Sonication is recommended.
H2O : Insoluble
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (8.16 mM), Sonication is recommended.
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| Keywords | R-14950 | R14950 | R 14950 | Flunarizine |
| Inhibitors Related | Quadrol | 2,4,6-Tri-tert-butylphenol | Phenytoin sodium | Chlorocresol | L-Ascorbic acid | Hexamethonium Bromide | Valproic Acid | L-Aspartic aicd sodium | L-Ascorbic acid sodium salt | 2-Nitrobenzoic acid | Magnesium Chloride Hexahydrate | Magnesium sulfate |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Approved Drug Library | Sodium Channel Targeted Library | Calcium Channel Compound Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Human Metabolite Library |
United States
