| Name | Friedelin |
| Description | Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities. |
| In vitro | In in vitro antioxidant study, the free radical scavenging effect of Friedelin on 2,2-diphenyl-picrylhydrazyl (DPPH), hydroxyl, nitric oxide and superoxide radicals were evaluated. Friedelin showed very good scavenging effect on DPPH (IC50 21.1 mM), hydroxyl (IC50 19.8 mM), nitric oxide (IC50 22.1 mM) and superoxide (IC50 21.9 mM) radicals. Friedelin also showed strong suppressive effect on lipid peroxidation. In in vivo antioxidant study, CCl4 induced oxidative stress on rats produced significant increase in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and lactate dehydrogenase (LDH) levels along with reduction in liver superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione peroxidase (GPx) levels. Pre-treatment of rats with Friedelin at 40 mg/kg for 7 days restored these levels to normality and showed liver protection, comparable to the standard, silymarin (25 mg/kg)[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : Insoluble DMSO : Insoluble
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| Keywords | ProstaglandinReceptor | Prostaglandin Receptor | PGE | P450 | NOS | Inhibitor | inhibit | Friedelin | Cytochrome P450 | CYPs | Caspase |
| Inhibitors Related | Kaolin | Kojic acid | D(+)-Raffinose pentahydrate | Ipriflavone | Hydroxypropyl Cellulose | 1,8-Cineole | 1,4-Naphthoquinone | Tributyrin | Ethyl linoleate | N,N-Dimethylacetamide | Naringin | Gluconate Calcium |