| Name | Fucosterol |
| Description | Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression. |
| Cell Research | Cell Line: 3T3-L1 adipocytes. Concentration: 0 μM; 25 μM; 50 μM. Incubation Time: 7 days [1] |
| In vitro | Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα in fully differentiated control adipocytes [1], shows cytotoxicity against T47D and HT29 cell lines (IC50s: 27.94 and 70.41 μg/ml) [3], and decreases the proliferation of HEK293, MCF-7, and SiHa cells (IC50s: 185.4, 43.3, and 34.0 μg/ml) [4]. |
| In vivo | Fucosterol (p.o.; 30mg/kg) causes a significant decrease in serum glucose concentrations and exhibits inhibition of sorbitol accumulations in the lenses [2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% EtOH+90% Corn Oil : 1.5 mg/mL (3.63 mM), Sonication is recommended. Ethanol : 17.76 mg/mL (43.03 mM), Sonication is recommended.
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| Keywords | PPARα | poly ADP ribose polymerase | PARP | Inhibitor | inhibit | Fucosterol | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
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