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Fudosteine NEW

$ 34.00 /200mg

Min. Order
Purity99.81%
Cas No13189-98-5
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP4Y

United States

United States

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Chemical Properties

Product Name	Fudosteine
CAS No	13189-98-5
EC-No
Min. Order
Purity	99.81%
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	Fudosteine
Description	Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.
In vitro	Fudosteine (FDS), a unique mucolytic antioxidant, shows a stronger scavenging effect of Peroxynitrite than N-acetyl-cysteine on DCDHF oxidation in vitro and in sputum macrophages, and also on Peroxynitrite-induced BSA nitration. Fudosteine (0.1 mM) reduces Peroxynitrite-enhanced interleukin (IL)-1beta-induced IL-8 release and restores corticosteroid sensitivity defected by Peroxynitrite more potently than those induced by H(2)O(2) in A549 airway epithelial cells. [1] Fudosteine significantly inhibits increases in GRO/CINC-1 at 10-100 mg/kg, and neutrophils and goblet cells at 30 and 100 mg/kg. Fudosteine inhibits goblet cell hyperplasia by inhibiting GRO/CINC-1 production and/or neutrophil migration. [2] Fudosteine treatment reduces the expression levels of p-p38 MAPK and p-ERK in vivo and of p-ERK in vitro. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro. [3] Fudosteine significantly suppresses blood flow of tracheal microvasculature increased by SO(2) exposure. Fudosteine scavenges superoxide anion generated from rat neutrophils, and enzymatically generated from xanthine oxidase-acetaldehyde reaction. [4]
In vivo	Fudosteine (500 mg/kg, p.o.) significantly increases the amount of dye excreted into the respiratory tract. Fudosteine increases chloride ion concentration in broncho-alveolar lavage of rats. [5]
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O : 10 mM, Sonication is recommended. DMSO : Insoluble
Keywords	mucoactive \| MUC5AC mucin hypersecretion \| MUC5AC \| mRNA \| Inhibitor \| inhibit \| Fudosteine \| derivative \| cysteine
Inhibitors Related	Boc-Lys(Boc)-OH \| Aceglutamide \| H-DL-Abu-OH \| N-Methylsarcosine \| DL-Proline \| Sodium lauroyl glutamate \| L-Ornithine L-aspartate \| Fmoc-Aib-OH \| Fmoc-L-aspartic acid \| H-Glu(OEt)-OEt.HCl \| Fmoc-His(Trt)-OH \| Fmoc-Lys(Alloc)-OH
Related Compound Libraries	FDA-Approved & Pharmacopeia Drug Library \| Bioactive Compound Library \| Approved Drug Library \| ReFRAME Related Library \| Drug-induced Liver Injury (DILI) Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| NO PAINS Compound Library \| Orally Active Compound Library \| Immunology/Inflammation Compound Library \| Bioactive Compounds Library Max \| Human Metabolite Library

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