| Name | Fumagillin |
| Description | Fumagillin (Amebacilin) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis. |
| In vitro | Fumagillin selectively inhibits the growth of a Δmap1 strain but not a wild-type or a Δmap2 S. cerevisiae strain missing MetAP-2. [1] In budding yeast cells, as a potent inhibitor of angiogenesis, Fumagillin not only reverses the growth inhibitory activity of Vpr, but also inhibits Vpr-dependent viral gene expression upon the infection of human macrophages. [3] Though the toxicity of fumagillin has limited its use for human applications, the analogues using structure-activity relationships relating to its angiogenesis properties may be further explored in the treatment of angiogenesis-dependent diseases. [4] |
| In vivo | In DEN-treated rats, fumagillin (30 mg/kg, i.p.) inhibits both progression of HCC in the liver itself and systemic metastasis. [2] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.36 mM), Sonication is recommended.
DMSO : 50 mg/mL (109.04 mM), Sonication is recommended.
|
| Keywords | Parasite | NSC-9168 | NSC 9168 | MetAP2 | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV Protease | HIV | Fumagillin | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Stavudine | Emtricitabine | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Lamivudine | Metronidazole | 2-Amino-2-methyl-1-propanol | Doxycycline | Fenpyroximate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Highly Selective Inhibitor Library | Bioactive Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Natural Product Library | Antiparasitic Natural Product Library | Inhibitor Library | Microbial Natural Product Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max |
United States
