| Name | Furamidine dihydrochloride |
| Description | Furamidine dihydrochloride (DB75 dihydrochloride) is a cell-permeable, selective small molecule inhibitor of protein arginine methyltransferase 1 (PRMT1) that also binds preferentially to strings of AT base pair sequences within the minor groove of DNA; it targets the PRMT1 enzyme active site primarily through a competitive mechanism with the protein substrate and is noncompetitive toward the cofactor, ultimately leading to the blockade of cell proliferation in various leukemia cell lines irrespective of their genetic lesions. |
| In vitro | Furamidine dihydrochloride (20 μM, 72 hours) treatment of leukemia cell lines inhibited cell growth in most leukemia cell lines except HEL cells harboring the JAK2V617F mutation.[6] |
| In vivo | Furamidine dihydrochloride (1 mg/kg, intraperitoneal injection, 3 times a week, repeated every 4 weeks for 34 weeks) was used to treat female NZB/NZW mice and was found to suppress proteinuria and prolong the survival of lupus-prone NZB/NZW mice when combined with irinotecan. [5] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mg/mL (26.51 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.65 mM), Sonication is recommended.
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| Keywords | Furamidine HCl | Furamidine Dihydrochloride | Furamidine | DB 75, DB75, NSC 305831, WR-199385 | DB 75, DB75, NSC 305831, WR199385 | DB 75, DB75, NSC 305831, WR 199385 |
| Inhibitors Related | Gum arabic | Kojic acid | Urethane | D(+)-Raffinose pentahydrate | Hydroxychloroquine | Metronidazole | Avermectin B1a | 2-Amino-2-methyl-1-propanol | Doxycycline | Fenpyroximate | Methylene Blue trihydrate | Sildenafil citrate |
| Related Compound Libraries | Histone Modification Compound Library | Anti-Parasitic Compound Library | Bioactive Compound Library | Epigenetics Compound Library |
United States
