| Name | FX-11 |
| Description | FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer. |
| In vitro | FX-11 (9 μM, 24-48 h) induces activation of AMP kinase and phosphorylation of acetyl-CoA carboxylase, its substrate. FX-11 disrupts glycolysis and modifies cellular energy metabolism in P493 cells. [1]
FX-11 (0-100 µM, 72 h) impedes cell proliferation in BxPc-3 and MIA PaCa-2 cells. [2] |
| In vivo | FX-11 (42 µg/mouse; IP, administered daily for 10-14 days) suppresses P493 tumor growth.[1]
FX-11 (0-2 mg/kg, IP, daily, for 3 weeks) notably retards tumor growth.[2] |
| Storage | Store at low temperature,Keep away from moisture | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (14.27 mM), Sonication is recommended. DMSO : 260 mg/mL (741.99 mM), Sonication is recommended.
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| Keywords | LDHA, HeLa cell | LDHA | FX-11 | FX11 | FX 11 |
| Inhibitors Related | Ethoxyquin | Kaolin | Stavudine | Aceglutamide | Allopurinol | Tamoxifen | Urea | Cysteamine hydrochloride | Metronidazole | Ethyl linoleate | Formamide | Alginic acid |
| Related Compound Libraries | Ferroptosis Compound Library | NF-κB Signaling Compound Library | Glycometabolism Compound Library | Bioactive Compound Library | Hematonosis Compound Library | Inhibitor Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |