| Name | G-418 disulfate |
| Description | G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic that selectively inhibits eukaryotic protein synthesis by blocking peptide chain elongation. |
| In vitro | Continuous administration of G418 at doses ranging from 40 to 80 mg/kg for three consecutive days is sufficient to eradicate all untransfected Brucella bacterium parasites in infected mice. |
| In vivo | At concentrations ranging from 1 to 300 micrograms/ml, G418 inhibits a variety of prokaryotic and eukaryotic organisms. Typically, concentrations of 5 mg/L or lower are effective against bacteria and algae, while a concentration of 400 mg/L is used for the selection of mammalian cells, and a maintenance concentration for mammalian cells is set at 200 mg/L. |
| Storage | store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 252 mg/mL (363.79 mM), Sonication is recommended.
DMSO : Insoluble
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| Keywords | synthesis | protein | Inhibitor | inhibit | Geneticin Sulfate | G-418 Sulfate | G-418 disulfate | G418 disulfate | G-418 | G418 | G 418 Sulfate | G 418 disulfate | G 418 | eukaryotic | cells | Bacterial | Antibiotic G-418 Sulfate | Antibiotic G418 Sulfate | Antibiotic G-418 | Antibiotic G418 | Antibiotic G 418 Sulfate | Antibiotic G 418 | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Antibiotics Library | Natural Product Library | Saccharide and Glycoside Natural Product Library | Microbial Natural Product Library | Anti-Bacterial Compound Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Human Metabolite Library |
United States
