| Name | Galanin Receptor Ligand M35 TFA |
| Description | Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of the galanin receptor (Kd = 0.1 nM). |
| In vitro | Galanin Receptor Ligand M35 TFA exhibits dual effects on galanin-mediated inhibition of Forskolin-stimulated cyclic AMP production in Rin m 5F cells. At low concentrations (1 nM), co-applied with galanin (10 nM), it reverses galanin's inhibitory effect, while at higher concentrations (15 and 30 nM), it functions as a galanin receptor agonist, inhibiting cAMP production. These effects are not additive, reflecting its mixed agonist/antagonist properties due to its chimeric nature acting solely at galanin receptors[1]. |
| In vivo | Galanin Receptor Ligand M35 TFA (6 nM/10 μL; i.c.v.) enhances the performance of male Sprague-Dawley rats in the swim maze task by shortening escape latency, reducing failure rates in reaching the platform, and decreasing path length to the hidden platform[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mM, Sonication is recommended.
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| Keywords | NeuropeptideYReceptor | Neuropeptide Y Receptor | Galanin Receptor Ligand M-35 TFA | Galanin Receptor Ligand M35 TFA | galanin receptor |
| Inhibitors Related | [Leu31,Pro34]-Neuropeptide Y (porcine) | Lu AA33810 | (S)-VU0637120 | Galanin (1-16), mouse, porcine, rat | SF 11 | GW438014A | M617 acetate | JNJ-31020028 | Galantide acetate | DF-1012 FA | M871 acetate | Pancreatic Polypeptide (human) acetate |
| Related Compound Libraries | Peptide Compound Library | NO PAINS Compound Library |
United States
