| Name | Galanthamine hydrobromide |
| Description | Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors. |
| In vitro | Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. [1] Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). [2] Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells. [3] |
| In vivo | Galantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 35.59 mg/mL (96.64 mM), Sonication is recommended.
H2O : 18.2 mg/mL (49.42 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.72 mM), Sonication is recommended.
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| Keywords | Nicotinic acetylcholine receptors | neurodegenerative | nAChR | Inhibitor | inhibit | Galanthamine hydrobromide | Galanthamine | Galantamine Hydrobromide | Galantamine | disease (AD) | disease | Cholinesterase (ChE) | Alzheimer's | AChE | acetylcholinesterase |
| Inhibitors Related | Adiphenine hydrochloride | Levamisole hydrochloride | Urethane | Ribavirin | Diethyltoluamide | Adenine | Mitotane | N,N-Dicyclohexylcarbodiimide | Dimethyl sulfoxide | Coumaran | Arecoline | Trimethylammonium chloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Alkaloid Natural Product Library | Drug Repurposing Compound Library | Inhibitor Library | NO PAINS Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | NMPA-Approved Drug Library |
United States
