| Name | Galanthamine hydrobromide |
| Description | Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors. |
| In vitro | Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. [1] Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). [2] Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells. [3] |
| In vivo | Galantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (162.92 mM), Heating is recommended.
H2O : 7.4 mg/mL (20.09 mM), Sonication is recommended.
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| Keywords | Nicotinic acetylcholine receptors | neurodegenerative | nAChR | Inhibitor | inhibit | Galanthamine hydrobromide | Galanthamine Hydrobromide | Galanthamine | Galantamine Hydrobromide | Galantamine | disease (AD) | disease | Cholinesterase (ChE) | Alzheimer's | AChE | acetylcholinesterase |
| Inhibitors Related | Adiphenine hydrochloride | Nanofin | Clozapine N-Oxide | Urethane | Ribavirin | 4-Methylbenzylidene camphor | Diethyltoluamide | D-Menthol | Choline chloride | Propoxur | Methyl tridecanoate | Trimethylammonium chloride |
| Related Compound Libraries | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Alkaloid Natural Product Library | Membrane Protein-targeted Compound Library | Natural Product Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
United States
