| Name | Garcinol |
| Description | Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively. |
| In vitro | Garcinol (10-50 μM; 24-72 hours) induces apoptosis and inhibits the proliferation of HNSCC cells in a time- and dose-dependent manner, specifically in the cell lines CAL27 and UMSCC1. Additionally, Garcinol (50 μM; 1-6 hours) suppresses the phosphorylation and degradation of constitutive IκBα in a time-dependent manner. |
| In vivo | Garcinolinduces significant inhibition of tumor growth. |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 20 mg/mL (33.18 mM), Sonication and heating are recommended.
DMSO : 20 mg/mL (33.18 mM), Sonication and heating are recommended.
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| Keywords | PCAF | Inhibitor | inhibit | indica | HistoneAcetyltransferase | Histone Acetyltransferase | HATs | HAT | Garcinol | Garcinia | EndogenousMetabolite | Endogenous Metabolite | Cholinesterase (ChE) | BChE | Apoptosis | anti-inflammatory | anti-cholinesterase | anti-cancer | AChE |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Glycerol | Thymidine | Corn starch | N,N-Dicyclohexylcarbodiimide | Gluconate Calcium | Dimethyl sulfoxide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Histone Modification Compound Library | Bioactive Compound Library | Rare Natural Product Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | Selected Plant-Sourced Compound Library | Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
United States
