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ChemicalBook Product Catalog Gboxin

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Gboxin NEW

$37.00 1mg

$53.00 2mg

$85.00 5mg

Min. Order
Purity99.96%
Cas No2101315-36-8
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

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United States

United States

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Chemical Properties

Product Name	Gboxin
CAS No	2101315-36-8
EC-No
Min. Order
Purity	99.96%
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	Gboxin
Description	Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.
In vitro	Gboxin, a small molecule that specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes.?Gboxin rapidly and irreversibly compromises oxygen consumption in glioblastoma cells.?Gboxin relies on its positive charge to associate with mitochondrial oxidative phosphorylation complexes in a manner that is dependent on the proton gradient of the inner mitochondrial membrane, and it inhibits the activity of F0F1 ATP synthase.?Gboxin-resistant cells require a functional mitochondrial permeability transition pore that regulates pH and thus impedes the accumulation of Gboxin in the mitochondrial matrix.?Administration of a metabolically stable Gboxin analogue inhibits glioblastoma allografts and patient-derived xenografts.?Gboxin toxicity extends to established human cancer cell lines of diverse organ origin, and shows that the increased proton gradient and pH in cancer cell mitochondria is a mode of action that can be targeted in the development of antitumour reagents.
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O : 10 mg/mL (25.45 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.09 mM), Sonication is recommended. DMSO : 30 mg/mL (76.34 mM), Sonication is recommended.
Keywords	MitochondrialMetabolism \| Mitochondrial Metabolism \| Inhibitor \| inhibit \| Gboxin \| F0F1 ATP synthase \| F0F1 ATP synthase \| ATP Synthase
Inhibitors Related	Ciprofloxacin hydrochloride monohydrate \| Phenoxyethanol \| 1-Hexanol \| Imeglimin hydrochloride \| Rotenone \| Sodium oleate \| (-)-Epigallocatechin Gallate \| Sodium Molybdate \| 4-Pentenoic acid \| Revaprazan hydrochloride \| 4'-Hydroxychalcone \| L-Histidine
Related Compound Libraries	Cuproptosis Compound Library \| Glycometabolism Compound Library \| Mitochondrial Membrane Protein-Targeted Compound Library \| Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Inhibitor Library \| NO PAINS Compound Library \| Mitochondria-Targeted Compound Library \| Metabolism Compound Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Active Compound Library

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