| Name | Glimepiride |
| Description | Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity. |
| In vitro | In both normal and insulin-resistant adipocytes, as well as in myocytes, Glimepiride effectively stimulates glucose transport, and the synthesis of lipids and glycogen. In cardiomyocytes, Glimepiride (IC50=6.8 nM) inhibits the pinacidil-activated whole-cell K(ATP) current. Additionally, in HEK 293 cells, Glimepiride (IC50=6.2 nM) blocks the K(ATP) channels formed by the co-expression of Kir6.2/SUR2A subunits. |
| In vivo | Within diabetic rats, Glimepiride has been shown to decrease the incidence of sperm abnormalities, enhance sperm count, and bolster antioxidant capacity. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 30 mg/mL (61.15 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 1.5 mg/mL (3.06 mM), Sonication is recommended.
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| Keywords | SUR2B | SUR2A | SUR1 | PotassiumChannel | Potassium Channel | Inhibitor | inhibit | HOE490 | HOE 490 | Glimepiride |
| Inhibitors Related | Minoxidil sulfate | Benzenesulfonamide | Tannic acid | HEPPS | Hydrochlorothiazide | 1,8-Cineole | Tetraethylammonium bromide | Rutin | 10-Undecenoic acid | 2,4-Di-tert-butylphenol | Chlorzoxazone | Indapamide |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bitter Compound library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
United States
