| Name | Gliquidone |
| Description | Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity, exhibiting greater binding affinity to SUR1 and increased potency compared to first-generation compounds. Additionally, this agent exerts peroxisome proliferator-activated receptor (PPAR) gamma agonistic activity. |
| In vitro | Intraventricular administration of 0.06–16 μg Gliquidone to each mouse counteracts the antinociceptive effects of tramadol, morphine, and methadone. A dose of 6 μg Gliquidone intraventricularly administered to each mouse inhibits the antinociceptive responses induced by subcutaneous injections of 0.125 mg/kg clonidine and 0.30 mg/kg chlorthalidone; however, a 3 μg dose is ineffective. In male Swiss albino mice, intraventricular injections of 0.1–1.0 μg Gliquidone dose-dependently suppress the antinociceptive effects of amitriptyline and chlorphenamine. In diabetic rats, a 10 mg/kg dose of Gliquidone significantly reduces blood pressure, diminishes non-enzymatic glycation, lowers total protein levels in the lens, and notably increases glutathione levels in the lens. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 3.3 mg/mL (6.25 mM), Sonication is recommended.
DMSO : 250 mg/mL (473.82 mM), Sonication is recommended.
Ethanol : 6 mg/mL (11.37 mM), Sonication is recommended.
|
| Keywords | PotassiumChannel | Potassium Channel | Inhibitor | inhibit | Gliquidone |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Urea | Rhamnose monohydrate | D(+)-Raffinose pentahydrate | Hydroxypropyl Cellulose | Ethyl linoleate | Magnesium acetate tetrahydrate | Trometamol | Gluconate Calcium | Dimethyl phthalate |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | NO PAINS Compound Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Human Metabolite Library | Anti-Cancer Drug Library |
United States
