Basic information Safety Related Supplier

ChemicalBook Product Catalog GLPG0492

1/1

GLPG0492 NEW

$68.00 1mg

$167.00 5mg

$248.00 10mg

Min. Order
Purity99.58%
Cas No1215085-92-9
Supply Ability10g
Update time2026-04-12

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

show more

Enterprise Verified

Business Bank account Basic Contact Infomation Business Address Trade Company

Chemical Properties

Product Name	GLPG0492
CAS No	1215085-92-9
EC-No
Min. Order
Purity	99.58%
Supply Ability	10g
Release date	2026/04/12

Product Introduction

Bioactivity

Name	GLPG0492
Description	GLPG0492 is a novel selective androgen receptor modulator. After oral dosing, it showed anabolic activity on muscle, strongly dissociated from the androgenic activity on the prostate.
In vitro	GLPG0492 is a new non-steroidal selective androgen receptor modulator that is currently under development for musculo-skeletal diseases such as sarcopenia and cachexia. GLPG0492 was found as efficacious as TP at reducing muscle loss while sparing reproductive tissues. GLPG0492 treatment partially prevents immobilization-induced muscle atrophy with a trend to promote muscle fiber hypertrophy in a dose-dependent manner. AR modulator GLPG0492 has very good pharmacokinetic properties, including bioavailability in rat (F > 50%), and is currently under evaluation in phase I clinical trials [1]. A surrogate of the 6-min walking test used in DMD patients, GLPG0492 preserved running performance, in acute exhaustion tests. Whereas vehicle- or comparator-treated animals showed a significant increase in fatigue (30-50%) [2]. Furthermore, gene expression studies performed on tibialis samples revealed that both GLPG0492 and TP were slowing down muscle loss by negatively interfering with major signaling pathways controlling muscle mass homeostasis [3].
Storage	02 \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.14 mM), Sonication is recommended. DMSO : 45 mg/mL (115.58 mM), Sonication is recommended.
Keywords	GLPG-0492 \| GLPG0492 \| GLPG 0492 \| AndrogenReceptor \| Androgen Receptor
Inhibitors Related	Dehydroisoandrosterone 3-acetate \| Bicalutamide \| 2-Ethylhexyl trans-4-methoxycinnamate \| S-23 \| Enzalutamide \| Octinoxate \| Testosterone propionate \| Allura Red AC \| Sunset Yellow FCF \| Ostarine \| 2-sec-Butylphenol \| Flutamide
Related Compound Libraries	Nuclear Receptor Compound Library \| Bioactive Compound Library \| ReFRAME Related Library \| Drug Repurposing Compound Library \| Endocrinology-Hormone Compound Library \| Anti-Prostate Cancer Compound Library \| Clinical Compound Library \| Bioactive Compounds Library Max \| Fluorochemical Library \| Transcription Factor-Targeted Compound Library

show more

Company Profile Introduction

You may like

Recommended supplier

Send Inquriy