| Name | Glucagon (1-29), bovine, human, porcine |
| Description | Glucagon (1-29), bovine, human, porcine is a hormone produced by pancreatic α-cells with glucagon activity, which promotes glycogenolysis and gluconeogenesis, and is used in the study of obesity and diabetes. |
| In vitro | Glucagon (1-29), bovine, human, porcine binds to its receptor Gcgr and activates the cAMP-PKA signaling pathway, which in turn promotes hepatic gluconeogenesis and triggers hyperglycemia. In addition, Glucagon (1-29), bovine, human, porcine stimulates hepatic production of kisspeptin1 and gluconeogenesis. [1]
Glucagon (1-29), bovine, human, porcine inhibits the expression of CYP7A1 mRNA in human primary hepatocytes at a concentration of 100 nM and increases the phosphorylation of HNF4α. increased the phosphorylation level of HNF4α. [3] |
| In vivo | A low dose of 20 μg/kg Glucagon (1-29), bovine, human, porcine increased blood glucose but did not stimulate insulin secretion in mice fed in a normal environment. A high dose of 1 mg/kg Glucagon (1-29), bovine, human, porcine lowered blood glucose and stimulated insulin secretion in mice fed in a normal environment compared to the PBS control. [4] |
| Storage | keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 1 mg/mL (0.29 mM), Sonication is recommended.
H2O : 4 mg/mL (1.15 mM), when pH is adjusted to 2 with HCl. Sonication is recommmended.
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| Keywords | Porcine glucagon(1-29), bovine, human, porcine | GlucagonReceptor | Glucagon Receptor | Glucagon , bovine, human, porcine | Glucagon (129), bovine, human, porcine | Glucagon (1 29), bovine, human, porcine | GCGR |
| Inhibitors Related | Exendin-4 | Exendin-4 acetate | Semaglutide | (S, R)-LSN 3318839 | NNC 92-1687 | Liraglutide | Semaglutide Acetate | 6α-Methylprednisolone 21-hemisuccinate sodium salt | MK-0626 | Orforglipron | Tirzepatide Acetate(2023788-19-2 free base) | LSN3318839 |
United States
