| Name | Glucosamine |
| Description | Glucosamine (Chitosamine) is a natural product. Glucosamine is used as a dietary supplement. Glucosamine has pharmacological effects on cartilage and chondrocytes in osteoarthritis when used externally. Glucosamine regulates sugar metabolism. Glucosamine reduces the activity of glucoskinase in pancreatic islet homogenate. |
| In vitro | METHODS: YD-8 human tongue cancer cells were treated with Glucosamine (10 mM) for 4 hours, and the phosphorylation levels of related proteins were detected by western blot.
RESULTS: Glucosamine inhibits HIF-1α and reduces the phosphorylation of p70S6K and S6 translation-related proteins. [1]
METHODS: Renal cells were treated with Glucosamine (5 mM) for 12, 24 and 36 hours, and the expression level of target proteins was detected by western blot.
RESULTS: Glucosamine significantly reduced the renal expressions of α -smooth muscle actin, collagen I and fibronectin in obstructive kidneys and renal cells treated with TGF-β1. [2] |
| In vivo | METHODS: To study the effect of Glucosamine on bone injury, Glucosamine (20 mg/kg/day) was orally administered to mice for 30 consecutive days.
RESULTS: Glucosamine significantly reduces cartilage damage and osteophyte formation. [3] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 200.9 mM, Sonication is recommended.
DMSO : 58 mg/mL (323.71 mM), Sonication is recommended.
|
| Keywords | TNF-α | ReactiveOxygenSpecies | Reactive Oxygen Species | NF-κB | NFκB | NF-kB | NFkB | MMP-9 | Inhibitor | inhibit | IFγ | Hypoxia-inducible factors | HIFs | HIFProlylHydroxylase | HIF-PH | HIF/HIFProlylHydroxylase | HIF/HIF Prolyl-Hydroxylase | HIF/HIF ProlylHydroxylase | HIF Prolyl-Hydroxylase | HIF ProlylHydroxylase | HIF | Glucosamine | EndogenousMetabolite | Endogenous Metabolite | Chitosanase | Autophagy |
| Inhibitors Related | Sucrose | Aceglutamide | Hemin | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Ethyl linoleate | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Saccharide and Glycoside Natural Product Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Natural Product Library for HTS | Cosmetic Ingredient Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-Cancer Drug Library |
United States
