| Name | Glutaric acid |
| Description | Glutaric acid is a simple five-carbon linear dicarboxylic acid. Glutaric acid is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan |
| In vitro | Glutaric acid, at concentrations of 1 and 2 mM, significantly reduces TRAP measurement by up to 28%, showcasing a dose-dependent efficacy (β=0.77; P<0.001). Additionally, a strong inverse correlation is observed between chemiluminescence and TRAP levels (β=0.81; P<0.001), indicating glutaric acid's potential impact on these parameters. Despite not affecting the activities of catalase (Cat) and superoxide dismutase (SOD), glutaric acid notably inhibits glutathione peroxidase (GPx) activity by up to 46%, starting at a minimal concentration of 0.5 mM. This inhibition is further confirmed to follow a dose-dependent pattern, beginning from concentrations as low as 0.05 mM[2], underscoring its potent and variable effect based on the dosage administered. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : Soluble
DMSO : 55 mg/mL (416.32 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (15.14 mM), Sonication is recommended.
H2O : 5 mg/mL (37.85 mM), Sonication is recommended.
|
| Keywords | Inhibitor | inhibit | Glutaric acid | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Bioactive Compound Library | Natural Product Library | Tobacco Monomer Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Human Endogenous Metabolite Library | Cosmetic Ingredient Compound Library | Flavor Natural Product library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Human Metabolite Library |
United States
