| Name | Glycolic acid |
| Description | Glycolic acid, an inhibitor of tyrosinase, suppresses melanin formation and is used in skincare products. |
| Animal Research | The effects of different concentrations of Glycolic acid(GA) on the inflammatory response of human keratinocytes HaCaT cells and C57BL/6J mice dorsal skin.?After GA was topically applied, HaCaT and mice skin were exposed to UVB irradiation[1]. |
| In vivo | Glycolic acid(GA) reduced the production of UVB-induced nuclear factor kappa B (NF-κB)-dependent inflammatory mediators [interleukin (IL)-1β, IL-6, IL-8, cyclooxygenase (COX)-2, tumor necrosis factor-α, and monocyte chemoattractant protein (MCP-1)] at both mRNA and protein levels. GA inhibited the UVB-induced promoter activity of NF-κB in HaCaT cells. GA attenuated the elevation of senescence associated with β-galactosidase activity but did not affect the wound migration ability. The topical application of GA inhibited the genes expression of IL-1β, IL-6, IL-8, COX-2, and MCP-1 in UVB-exposed mouse skin. The mice to UVB irradiation after GA was topically applied for 9 consecutive days and reported that 1-1.5% of GA exerted anti-inflammatory effects on mouse skin[1] |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (26.3 mM), Sonication is recommended.
DMSO : 50 mg/mL (657.46 mM), Sonication is recommended.
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| Keywords | Tyrosinase | Inhibitor | inhibit | Glycolic acid | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Ethyl linoleate | Formamide | Glycerol | Thymidine | Corn starch | Hyaluronic acid sodium (MW 20 kDa) | Gluconate Calcium |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Natural Product Library | Drug Repurposing Compound Library | Miao medicine Compound Library | Tobacco Monomer Library | Inhibitor Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Food as Medicine Compound Library |
United States
