| Name | Glycyrrhizic acid |
| Description | Glycyrrhizic acid (Glycyrrhizin), the active ingredient in licorice, is a triterpene saponins and an antagonist of HMGB1. Glycyrrhizic acid has the potential to be used in cancer, diabetes and other research. |
| In vitro | METHODS: MDCK cells were treated with Glycyrrhizic acid for 48 hours and cell growth inhibition was measured using MTT assay.
RESULTS: Glycyrrhizic acid inhibited the growth of MDCK cells (EC50=15.2 µM). [1]
METHODS: African green monkey Vero E6 cells were treated with Glycyrrhizic acid for 48 hours and cell growth inhibition was determined using MTT assay.
RESULTS: Glycyrrhizic acid showed no inhibitory effect on the growth of Vero E6 cells (CC50>100 µM). [2] |
| In vivo | METHODS: To study the anti-inflammatory activity of Glycyrrhizic acid, Glycyrrhizic acid (50 mg/kg) was injected intraperitoneally to iodine-induced NOD.H-2h4 mice.
RESULTS: Dihydroartemisinin significantly reduced the levels of TgAb, HMGB1, TNF-α, IL-6, and IL-1β in the mice and effectively alleviated thyroiditis in the mice. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble)
5% DMSO+95% Saline : 4.65 mg/mL (5.65 mM), Solution.
Ethanol : 93 mg/mL (113.01 mM), Sonication is recommended.
DMSO : 257.5 mg/mL (312.91 mM), Sonication is recommended.
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| Keywords | VirusProtease | Virus Protease | MAO | Inhibitor | inhibit | Glycyrrhizic acid | Dehydrogenase |
| Inhibitors Related | Phenytoin sodium | Benzyl alcohol | 2-Methylaminoethanol | Methotrexate disodium | L-Lysine | L-Lysine hydrochloride | 1,4-Naphthoquinone | Ofloxacin | Paeonol | Vidarabine | Dimethyl malonate | Thymidine |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Anti-Neurodegenerative Disease Compound Library | Anti-Viral Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
