| Name | GNE-1858 |
| Description | GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA). |
| In vitro | HPK1 is a negative-feedback regulator of T cell receptor signaling, which dampens T cell proliferation and effector function.Hematopoietic progenitor kinase-1 (HPK1), a serine/threonine Ste20-related protein kinase whose expression is restricted to the hematopoietic compartment (e.g., T cells, B cells, and dendritic cells), is one such kinase. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 4.29 mg/mL (10.01 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.33 mM), Sonication is recommended.
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| Keywords | T-cell | signaling | regulator | receptor | proliferation | progenitor | negative-feedback | MAPK Kinase Kinase Kinase | MAP4K | Inhibitor | inhibit | HPK1 | hematopoietic | GNE-1858 | GNE1858 | GNE 1858 |
| Inhibitors Related | Sodium lauryl sulfoacetate | Phosphocreatine disodium hydrate | Vemurafenib | SKLB-163 | RV01 | Takinib | NG25 | Phosphocreatine disodium | RMM-46 | Oleanolic Acid | Dehydrocostus Lactone | Sodium new houttuyfonate |
| Related Compound Libraries | Anti-Colorectal Cancer Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Fibrosis Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library | MAPK Inhibitor Library |