| Name | GSK-3 inhibitor 3 |
| Description | GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau protein S396 with an IC50 of 10 nM in a triple transgenic mouse model of Alzheimer's disease. GSK-3 inhibitor 3 reduced the phosphorylation level of tau protein S396 in a triple transgenic mouse model of Alzheimer's disease, with an IC50 of 10 nM.GSK-3 inhibitor 3 can be used for the study of neurological diseases. |
| In vitro | GSK-3 inhibitor 3 (Compound 34) (1 μM) is a highly selective inhibitor of CDK2 and CDK5 with IC50s of 0.22 μM and 1.3 μM for CDK2 and CDK5, respectively.[1] |
| In vivo | GSK-3 inhibitor 3 (Compound 34) (2 mg/kg; i.v.;10 mg/kg orally; Alzheimer’s disease model using LaFerla 3xTg-C57BL6 mice) demonstrated a T1/2 of 2.5 hours (i.v.) in male C57BL6 mice and an oral bioavailability (F%) of approx. 100%.[1]
GSK-3 inhibitor 3 (10 mg/kg, single oral dose) reduces Tau 396 phosphorylation levels by 33% in a triple transgenic mouse model of Alzheimer's disease.[1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5.63 mg/mL (13.72 mM), Sonication is recommended.
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| Keywords | tau | MicrotubuleAssociated | Microtubule Associated | GSK3inhibitor3 | GSK-3 inhibitor 3 | GSK-3 | GSK3 |
| Inhibitors Related | Flubendazole | Cromolyn sodium | 4-Isopropoxybenzoic acid | 4-Chloro-2'-bromoacetophenone | Pregnenolone acetate | Ethyl linoleate | α-Cyclodextrin | Methylene Blue trihydrate | (E/Z)-10-Hydroxy-2-decenoic acid | 4'-Demethylepipodophyllotoxin | Albendazole | Colchicine |
| Related Compound Libraries | PI3K-AKT-mTOR Compound Library | Anti-Lung Cancer Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Microtubule-Targeted Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Liver Cancer Compound Library | Neuronal Differentiation Compound Library |
United States
