Basic information Safety Related Supplier

ChemicalBook Product Catalog GSK2837808A

1/1

GSK2837808A NEW

$40.00 1mg

$113.00 5mg

$179.00 10mg

Min. Order
Purity99.78%
Cas No1445879-21-9
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

show more

Enterprise Verified

Business Bank account Basic Contact Infomation Business Address Trade Company

Chemical Properties

Product Name	GSK2837808A
CAS No	1445879-21-9
EC-No
Min. Order
Purity	99.78%
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	GSK2837808A
Description	GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) with IC50 values of 1.9 nM for LDHA and 14 nM for LDHB.
In vitro	GSK2837808A inhibits lactate production in hypoxia but at higher concentrations than in normoxia (EC50=10 μM). It also reduces ECAR (EC50=10 μM). LDH inhibition by GSK2837808A alters multiple metabolic pathways in Snu398 cells. GSK2837808A rapidly and profoundly inhibits lactate production rates in multiple cancer cell lines including hepatocellular and breast carcinomas. GSK2837808A potency does not correlate with LDHA, LDHB, or the total LDH expression levels. The potency of GSK2837808A across 30 cancer cell lines with different LDHA and LDHB expression levels range from 400 nM to no effect (EC50 reported as 30 μM).
In vivo	GSK2837808A (p.o.; 50 mg/kg in rats; 100 mg/kg in mice) treatment, causes blood compound levels at or below the detection limit of 2.5 ng/mL. Clearance following IV infusion of GSK2837808A at 0.25 mg/kg is displayed to be 69 mL/minute/kg in rats and it exceeds the animal liver blood flow.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (6.16 mM), Sonication is recommended. DMSO : 102 mg/mL (157.01 mM), Sonication is recommended.
Keywords	LDHB \| LDHA \| LDH \| Lactate Dehydrogenase \| Inhibitor \| inhibit \| GSK-2837808A \| GSK2837808A
Inhibitors Related	Disulfiram \| Mycophenolate Mofetil \| Rotenone \| Ribavirin \| 18β-Glycyrrhetinic acid \| Benzyl alcohol \| 2-Methylaminoethanol \| Methotrexate disodium \| Dimethyl malonate \| Isomalt \| D-Mannitol \| Ethyl potassium malonate
Related Compound Libraries	Glycometabolism Compound Library \| Bioactive Compound Library \| Anti-Cancer Metabolism Compound Library \| Glutamine Metabolism Compound Library \| Multi-Target Compound Library \| Inhibitor Library \| NO PAINS Compound Library \| Metabolism Compound Library \| Bioactive Compounds Library Max \| Fluorochemical Library \| Anti-Metabolism Disease Compound Library

show more

Company Profile Introduction

You may like

Recommended supplier

Send Inquriy