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ChemicalBook Product Catalog Chemical Reagents Organic reagents Guanidine salt Guanidine hydrochloride

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Guanidine hydrochloride NEW

$ 29.00 /10g

Min. Order
Purity99.68%
Cas No50-01-1
Supply Ability10g
Update time2025-05-01

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP2Y

United States

United States

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Chemical Properties

Product Name	Guanidine hydrochloride
CAS No	50-01-1
EC-No
Min. Order
Purity	99.68%
Supply Ability	10g
Release date	2025/05/01

Product Introduction

Bioactivity

Name	Guanidine hydrochloride
Description	Guanidine hydrochloride (Aminoformamidine Hydrochloride) is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant.
In vitro	Guanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. [1] Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the molten globule state. Guanidine HCl (> 1 M) causes co-operative unfolding of the molten globule state. [2] Guanidine HCl is 2.8 times more effective than urea in unfolding ribonuclease but only 1.7 times more effective for lysozyme. △GWaterapp. values of Guanidine HCl are 9.7 Cal/mole for ribonuclease at pH 6.6, 6.1 for lysozyme at pH 2.9, 8.3 for α-chymotrypsin at pH 4.3, and 11.7 for β-lactoglobulin at pH 3.2. [3] Guanidine HCl at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI+] element from yeast cells. 5 mM Guanidine HCl in growth media cures [PSI+] and other prions of yeast. [4] 5 mM Guanidine HCl significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine HCl also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase. [5]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 50 mg/mL (523.4 mM), Sonication is recommended. H2O : 198.9 mM, Sonication is recommended.
Keywords	unfolded \| RNASynthesis \| RNA Synthesis \| Ribonuclease pancreatic \| proteins \| Lysozyme \| Inhibitor \| inhibit \| Hsp104 \| Guanidinium Chloride \| Guanidinium \| Guanidine hydrochloride \| Guanidine Hydrochloride \| Guanidine \| EndogenousMetabolite \| Endogenous Metabolite \| DNASynthesis \| DNA Synthesis \| denaturant \| chaotrope \| Argininosuccinate synthase \| Arginase \| Aminoformamidine
Inhibitors Related	Sucrose \| Stavudine \| Hydroxychloroquine \| Daidzein \| Fumaric acid \| Ferulic Acid \| Formamide \| Paeonol \| Glycerol \| Thymidine \| Naringin \| 3-Indoleacetic acid
Related Compound Libraries	Anti-Tumor Natural Product Library \| Traditional Chinese Medicine Monomer Library \| Natural Product Library \| Drug Repurposing Compound Library \| Anti-Inflammatory Traditional Chinese Medicine Compound Library \| Anti-Cancer Approved Drug Library \| Natural Product Library for HTS \| Anti-infective Natural Product Library \| Human Endogenous Metabolite Library \| Immunology/Inflammation Compound Library \| Anti-Cancer Active Compound Library \| Anti-Cancer Drug Library

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