| Name | GW9508 |
| Description | GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner. |
| In vivo | In MIN6 cells, GW9508 stimulates insulin secretion in a dose-dependent manner and enhances insulin secretion mediated by KCl. In rat β-cells, GW9508 induces hyperpolarization and the opening of KATP channels. In HaCaT cells, GW9508 inhibits the expression of IL-11, IL-24, and IL-33 induced by TNF-α and IFN-γ. Additionally, in normal human epidermal keratinocytes, GW9508 suppresses the production of CCL5 and CXCL10. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 34.7 mg/mL (99.88 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (11.51 mM), Sonication is recommended. DMSO : 150 mg/mL (431.77 mM), Sonication is recommended.
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| Keywords | TNF-α | PotassiumChannel | Potassium Channel | KcsA | KATP | insulin | Inhibitor | inhibit | IFN-γ | GW-9508 | GW9508 | GPR40(FFA1) | GPR40 | GPR120 | glucose-sensitive | Free Fatty Acid Receptor | FFAR | FFA1 | CXCL10 | CCL5 | anti-inflammatory | anti-atherosclerotic |
| Inhibitors Related | Minoxidil sulfate | Tannic acid | Hydrochlorothiazide | 1,8-Cineole | Tetraethylammonium bromide | Ursodeoxycholic acid | Chenodeoxycholic acid | Minoxidil | Chlorzoxazone | 2,2,2-Trichloroethanol | Taurocholic acid sodium salt hydrate | Indapamide |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Anti-Obesity Compound Library | Neuroprotective Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Potassium Channel Targeted Library | Ion Channel Targeted Library | GPCR Compound Library | Anti-Cancer Compound Library |