| Name | Gypenoside L |
| Description | Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities. |
| In vitro | gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, on cancer cell growth.?We found that Gyp-L increased the SA-β-galactosidase activity, promoted the production of senescence-associated secretory cytokines, and inhibited cell proliferation of human liver and esophageal cancer cells.?Moreover, Gyp-L caused cell cycle arrest at S phase, and activated senescence-related cell cycle inhibitor proteins (p21 and p27) and their upstream regulators.?In addition, Gyp-L activated p38 and ERK MAPK pathways and NF-κB pathway to induce senescence.?Consistently, adding chemical inhibitors efficiently counteracted the Gyp-L-mediated senescence, growth inhibition, and cell cycle arrest in cancer cells.?Furthermore, treatment with Gyp-L, enhanced the cytotoxicity of clinic therapeutic drugs, including 5-fluorouracil and cisplatin, on cancer cells.?Overall, these results indicate that Gyp-L inhibits proliferation of cancer cells by inducing senescence and renders cancer cells more sensitive to chemotherapy[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (4.99 mM), Sonication is recommended.
DMSO : 166.67 mg/mL (208.07 mM), Sonication is recommended.
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| Keywords | saponin | ROS | p38MAPK | p38 MAPK | p38 | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | NFκB | NF-kB | NFkB | MAPK | Inhibitor | inhibit | Gypenoside L | Extracellular signal regulated kinases | ERK | cytokines | CalciumChannel | Calcium Channel | anti-tumor | anti-inflammatory |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | 2,4,6-Tri-tert-butylphenol | Urea | Gum arabic | Kojic acid | Ethyl linoleate | Magnesium acetate tetrahydrate | Gluconate Calcium | Dimethyl phthalate | Magnesium Chloride Hexahydrate |
| Related Compound Libraries | Rare Natural Product Library |
United States
