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ChemicalBook Product Catalog Biochemical Engineering Plant extracts Handelin

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Handelin NEW

$64.00 1mg

$178.00 5mg

$297.00 10mg

Min. Order
Purity99.34%
Cas No62687-22-3
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	Handelin
CAS No	62687-22-3
EC-No
Min. Order
Purity	99.34%
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	Handelin
Description	Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
In vitro	The present study was designed to investigate the anti-inflammatory potential of Handelin in vitro and in vivo. Handelin inhibited LPS-stimulated production of NO and PGE2 in cultured mouse macrophage RAW 264.7 cells. The suppression of NO and PGE2 production by Handelin was correlated with the down-regulation of mRNA and protein expressions of iNOS and COX-2. Further study revealed that Handelin suppressed the induction of pro-inflammatory cytokines including TNF-α± and IL-1β as well as microRNA-155 in LPS-induced RAW264.7 cells. Activation of the transcriptional activity of NF-κB by LPS was also alleviated by Handelin, which was well coincided with its inhibitory effect on IκB degradation. In addition, the activation of MAPKs such as ERK and JNK signaling was suppressed by Handelin. In in vivo animal model, oral administration of Handelin inhibited carrageenan-induced paw edema and TPA-induced ear edema, respectively. The analysis of cytokine production in serum showed that Handelin dose-dependently inhibited the production of IL-1β in a carrageenan-induced paw edema.
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	10% DMSO+90% Corn Oil : 1 mg/mL (1.81 mM), Sonication is recommended. DMSO : 10 mg/mL (18.09 mM), Sonication is recommended.
Keywords	TNF-α \| PGE \| Nuclear factor-κB \| Nuclear factor-kappaB \| NO Synthase \| NF-κB \| NFκB \| NF-kB \| NFkB \| Inhibitor \| inhibit \| Inflammationrelated \| Inflammation related \| inflammation \| Immunologyrelated \| Immunology related \| Handelin
Inhibitors Related	Undecane \| Sodium propionate \| Ethyl palmitate \| Kojic acid \| Uridine \| Fumaric acid \| Methylamine HCl \| 1,4-Naphthoquinone \| Glucosamine \| Ethyl linoleate \| N,N-Dimethylacetamide \| Magnesium sulfate
Related Compound Libraries	Terpene Natural Product Library \| Bioactive Compound Library \| Traditional Chinese Medicine Monomer Library \| Rare Natural Product Library \| Selected Plant-Sourced Compound Library \| Anti-Inflammatory Traditional Chinese Medicine Compound Library \| RO5 Drug-like Natural Product Library \| Immunology/Inflammation Compound Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library \| Food as Medicine Compound Library

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