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ChemicalBook Product Catalog HOIPIN-1.

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Min. Order
Purity98.83%
Cas No2470242-33-0
Supply Ability10g
Update time2026-04-10

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	HOIPIN-1.
CAS No	2470242-33-0
EC-No
Min. Order
Purity	98.83%
Supply Ability	10g
Release date	2026/04/10

Product Introduction

Bioactivity

Name	HOIPIN-1.
Description	HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-kB activation.
In vitro	In the HTRF-based analysis of LUBAC-mediated ubiquitination using Petit-LUBAC, the preincubation time of HOIPIN-1 (0.9-120 μM) in the reaction buffer correlates with increased inhibitory activity. The IC50 values at 1 h, 3 h, 6 h, and 24 h are 26 μM, 26 μM, 26 μM, and 3.926 μM, respectively[1]. Co-expression of LUBAC subunits in HEK293T cells increases the level of intracellular linear polyubiquitin chains. HOIPIN-1 (1-30 μM) dose-dependently inhibits the production of intracellular linear polyubiquitin chains in HEK293T cells expressing LUBAC[1]. In HeLa cells, HOIPIN-1 (30-100 μM; 30-60 minutes) inhibits IL-1β-induced NF-κB activation and reduces the phosphorylation of IKKα/β, p105, and p65. Furthermore, at doses of 10-100 μM, HOIPIN-1 dose-dependently inhibits the expression of NF-κB target genes such as ICAM1 and TNF-α induced by IL-1β in HeLa cells[1]. The linear ubiquitin chain assembly complex (LUBAC) consists of HOIL-1L, HOIP, and SHARPIN subunits. HOIPIN-1 inhibits the linear polyubiquitination activity of the HOIL-1L/HOIP complex, HOIL-1L/HOIP/SHARPIN complex, and HOIP/SHARPIN complex with IC50 values of 4.4 μM, 3.5 μM, and 3.7 μM, respectively[2]. In A549 cells, HOIPIN-1 (1-100 μM; 72 hours) shows no apparent cytotoxicity based on ATP content. However, it exhibits cytotoxicity in A549 cells with an IC50 > 100 μM[2].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 3.33 mg/mL (10.94 mM), Sonication is recommended.
Keywords	NF-κB \| NFκB \| NF-kB \| NFkB
Inhibitors Related	Myrcene \| Undecane \| Sodium propionate \| Ethyl palmitate \| Kojic acid \| Uridine \| Fumaric acid \| 1,4-Naphthoquinone \| Glucosamine \| Ethyl linoleate \| N,N-Dimethylacetamide \| Magnesium sulfate
Related Compound Libraries	Anti-Lung Cancer Compound Library \| NF-κB Signaling Compound Library \| Bioactive Compound Library \| HIF-1 Signaling Pathway Compound Library \| Hematonosis Compound Library \| Anti-Breast Cancer Compound Library \| Inhibitor Library \| Anti-Fibrosis Compound Library \| Immunology/Inflammation Compound Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Compound Library

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