| Name | Homatropine Methylbromide |
| Description | Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. |
| In vitro | Homatropine [14C]methylbromide administered rectally in rats achieved higher and quicker peak plasma concentrations compared to other routes. After 12 hours, 28% of the [14C] was excreted in the urine, with 56% remaining in the colon. Unlabeled homatropine methylbromide, delivered via a rectal suppository in anesthetized rats, rapidly blocked the effects of the vagus nerve on heart rate and of intravenous acetylcholine on blood pressure. A dose of 20 mg/kg homatropine increased the survival rate to 30% in rats poisoned with diazinon, with death occurring between 4 to 12 minutes, whereas a 10 mg/kg dose was ineffective in preventing mortality. |
| In vivo | When combined with hexamethonium, 20 μM Homatropine yields only a dose ratio of 95.0 in guinea pig atria. In contrast, 20 μM Homatropine alone produces a dose ratio of 259 in guinea pig atria. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (135.03 mM), Sonication is recommended.
Ethanol : 10 mg/mL (27.01 mM), Sonication is recommended.
H2O : 68 mg/mL (183.64 mM), Sonication is recommended.
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| Keywords | Muscarinic acetylcholine receptor | mAChR (WKY-E) | mAChR (SHR-E) | mAChR | Inhibitor | inhibit | Homatropine Methylbromide |
| Inhibitors Related | Adiphenine hydrochloride | Levamisole hydrochloride | Ethyl (triphenylphosphoranylidene) acetate | Urethane | Hexamethonium Bromide | Ribavirin | Adenine | Mitotane | Choline chloride | Propoxur | N,N-Dicyclohexylcarbodiimide | Arecoline |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Parkinson's Disease Compound Library | Toxic Compound Library | Drug Repurposing Compound Library | Inhibitor Library | NO PAINS Compound Library | FDA-Approved Drug Library | Orally Active Compound Library | Bioactive Compounds Library Max |
United States
