| Name | HPGDS inhibitor 1 |
| Description | HPGDS inhibitor 1 is a novel and selective inhibitor for Hematopoietic Prostaglandin D Synthase (HPGDS) with an IC50 Value of 0.7 nM. |
| Kinase Assay | Kinetic characterization of Abl inhibition: The ATP/NADH-coupled assay system in a 96-well format is used to determine the initial velocity of Abl tyrosine kinase catalyzed peptide phosphorylation. The reaction mixture contained 20 mM Tris-HCl, (pH 8.0), 50 mM NaCl, 10 mM MgCl2, 2 mM PEP [2-(Phosphonooxy)- 2-propenoic acid) and 20 μg Abl peptide substrate (EAIYAAPFAKKK), fixed or varied (to determine inhibitor kinetic parameters) concentration of inhibitor applied, 1/50 of the final reaction mixture volume of PK/LDH enzyme (pyruvate kinase/lactic dehydrogenase enzymes from rabbit muscle), 160 μM NADH, 0.16 μM Abl, and ATP added last to start the reaction. Absorbance data are collected every 20s at 340 nm using a SpectraMax M5 Microplate Reader. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 2.5 mg/mL (6.56 mM), Sonication is recommended.
DMSO : 55 mg/mL (144.22 mM), Sonication is recommended.
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| Keywords | Prostaglandin E synthase | PGESynthase | PGE synthase | PGD2 | orally | Inhibitor | inhibit | HPGDS inhibitor-1 | HPGDS inhibitor1 | HPGDS inhibitor 1 | hPGDS | asthma |
| Inhibitors Related | Zomepirac sodium salt | Pranoprofen | 4-ACETAMIDOANTIPYRINE | Bismuth Subsalicylate | Benzydamine | Zaloglanstat | Benzydamine hydrochloride | 1-O-Hexadecyl-Rac-Glycerol | Furprofen | hPGDS-IN-1 | F092 | PF-9184 |
| Related Compound Libraries | Nonsteroidal Anti-Inflammatory Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
United States
