| Name | HPPH |
| Description | HPPH (Photochlor) (Photochlor) is a second-generation photosensitizer. It is used as photodynamic therapy (PDT) agent. |
| In vitro | Cells treated with GO-PEG-HHPH displays a stronger fluorescence signal than those treated with free HPPH. In fact, the fluorescence of HPPH is rather weak. After 24 h, Fluorescence image of 4T1 cells incubated with 0.49 μg/mL GO-PEG, 1 μM HPPH (free HPPH), or equivalent amount of GO-PEG-HPPH (1 μM HPPH and 0.49 μg/mL GO-PEG). The cellular uptake of GO-PEG-HPPH and HPPH is investigated with 4T1 murine mammary cancer cells. The cells are incubated with GO-PEG-HPPH and free HPPH at equivalent HPPH concentration (1 μM) for 24 h and then observed with a confocal microscope [1]. |
| In vivo | A combination treatment regimen for Colo26-HA tumor-bearing BALB/c mice involves administering an HPPH-PDT (0.4 μmoles/kg HPPH followed by 665 nm light at 48 J/cm2) to enhance anti-tumor immunity. Following a 9-day rest period and an HPPH injection, tumors receive a control treatment with 665 nm light at 132 J/cm2 on day 10 [2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.14 mM), Sonication is recommended.
DMSO : 50 mg/mL (78.52 mM), Sonication is recommended.
H2O : < 0.1 mg/mL (insoluble)
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| Keywords | Inhibitor | inhibit | HPPH |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Cysteamine hydrochloride | Ethyl linoleate | Magnesium acetate tetrahydrate | Inosine | L-Cystine | Copper Sulfate Pentahydrate | Dimethyl itaconate | L-Ascorbic acid sodium salt | Dimethyl phthalate |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | NF-κB Signaling Compound Library | Failed Clinical Trials Compound Library | Bioactive Compound Library | ReFRAME Related Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
