| Name | HTHQ |
| Description | HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)), a hydroquinone monoalkyl ether, is an effective anti-oxidative agent. HTHQ is a potent anti-lipid-peroxidative compound and its antioxidation activity to be extremely elevated in biological systems, such as that of liver microsomes via the generation of stable free radicals. |
| In vitro | HTHQ has an anti-oxidative activity similar to D,L-alpha-tocopherol against lipid peroxidation in linolate micelles initiated by addition of Fe2+. The anti-lipid-peroxidation activity of HTHQ is higher 4.8-fold than that of D,L-alpha-tocopherol against the peroxidation in phosphatidylcholine liposomes initiated by addition of Fe2+. [1] The effects of 0.02% Glu-P-1 or 0.03% MeIQx on the number and area of foci is significantly reduced by 0.125% HTHQ. [2] |
| In vivo | Treatment with HTHQ potently inhibits PhIP-induced mammary carcinogenesis in female rats. Compared with DMN-induced hepatic fibrosis animals in the liver tissue, HTHQ reduced mRNA level of PDGF (Platelet-derived growth factor), α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β). In this study, we showed that HTHQ improves against DMN-induced liver fibrosis in male SD rats. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 43 mg/mL (181.93 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.46 mM), Sonication is recommended.
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| Keywords | ReactiveOxygenSpecies | Reactive Oxygen Species | Inhibitor | inhibit | HX-1171 | HX1171 | HTHQ | BTT-105 | BTT105 | BTT 105 |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Cysteamine hydrochloride | Ethyl linoleate | Magnesium acetate tetrahydrate | Inosine | L-Cystine | Copper Sulfate Pentahydrate | Dimethyl itaconate | L-Ascorbic acid sodium salt | Dimethyl phthalate |
| Related Compound Libraries | Cuproptosis Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Antioxidant Compound Library | Drug Repurposing Compound Library | NO PAINS Compound Library | Anti-Prostate Cancer Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
