| Name | Hycanthone |
| Description | Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits APE1 via direct protein binding(KD: 10 nM). |
| In vitro | Hycanthone at 20 mg/mL or more is progressively more detrimental to cell viability. Compared to that of controls, results show that increased concentrations of Hycanthone, ranging from 0.1 to 10 μg/mL, progressively decreases viral interferon yields as much as 73% [2]. |
| In vivo | Male worms treated with Hycanthone display signs of possible partial recovery from the initial low levels of incorporation. After treatment with Hycanthone, the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease. Immature worms are totally unaffected by Hycanthone at all times tested. In the first four days after treatment, incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50%. 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules [1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.81 mM), Sonication is recommended.
H2O : < 0.1 mg/mL (insoluble)
DMSO : 18 mg/mL (50.49 mM), Sonication is recommended.
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| Keywords | Topoisomerase II | Topoisomerase I | Topoisomerase | thioxanthenone | RNASynthesis | RNA Synthesis | Parasite | nucleic | Lucanthone | intercalator | Inhibitor | inhibit | Hycanthone | endonuclease-1 | DNASynthesis | DNA/RNA Synthesis | DNA Synthesis | biosynthesis | apurinic | APE1 | anti-schistosomal | acid |
| Inhibitors Related | Gum arabic | Kojic acid | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Avermectin B1a | 2-Amino-2-methyl-1-propanol | Doxycycline | 1,4-Naphthoquinone | Fenpyroximate | Thymidine | Methylene Blue trihydrate |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | ReFRAME Related Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Anti-Infection Compound Library | Human Metabolite Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
