Hydroxypropyl Tetrahydropyrantriol/Pro-xylane liquid oil solubility

Item Name: Pro-xylane liquid 

Appearance: colorless liquid ,Colorless to light yellow 

• CAS NO：439685-79-7

• C8H16O5

• 192.21 

• EINECS ：456-880-5

• Single S-configuration liquid 

• I. Differences in Basic Solubility

• 1. Water - Solubility Characteristics

• Procyanidin (hydroxypropyl tetrahydropyran triol) is a water - soluble component. Its molecular structure contains multiple hydroxyl groups, making it easily soluble in water or polar solvents 7, 16. In cosmetics, it often uses hydrophilic solvents such as propylene glycol and water as carriers, and can be directly dissolved in water - based formulations, which are suitable for dosage forms like essences and toners 2, 5.

• 2. Oil - Solubility Characteristics

• Procyanidin is naturally insoluble in oils and fats, but it can be made oil - soluble through formulation techniques (such as low - eutectic solvents) or chemical modifications (such as binding with lipid - soluble carriers). For example, by adding hydrogen - bond donors/acceptors like betaine and glycerin, ternary low - eutectic solvents are formed, enhancing its compatibility in oily systems 5, 17. 

• II. Differences in Formulation Design and Application

• Characteristics	Water - Soluble Formulation	Oil - Soluble Formulation
  Applicable Dosage Forms	Light - texture products such as essences, facial masks, and lotions 3	High - occlusion products such as face creams, oil - based essences, and ointments 11
  Penetration Efficiency	Relies on the skin's hydrophilic channels, but has weak penetration through the stratum corneum 5	Simulates the sebum film through lipid structures, making it easier to penetrate into the dermis 5, 17
  Stability	Easily affected by pH value, and should avoid being formulated with acidic components (such as salicylic acid) 7	More resistant to acid - base environments, and can be compatible with oil - soluble active ingredients (such as retinol) 11