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Hydroxystilbamidine NEW

$195.00 1mg

$447.00 5mg

$659.00 10mg

Min. Order
Purity98.11%
Cas No495-99-8
Supply Ability10g
Update time2026-03-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	Hydroxystilbamidine
CAS No	495-99-8
EC-No
Min. Order
Purity	98.11%
Supply Ability	10g
Release date	2026/03/13

Product Introduction

Bioactivity

Name	Hydroxystilbamidine
Description	Hydroxystilbamidine ((E)-hydroxystilbamidine), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases.
In vitro	Instructions I. Retrograde neural tracing 1. Material preparation: Hydroxystilbamidine (usually prepared as a 2% solution). Solvent: physiological saline, distilled water, or buffer (such as PBS) according to experimental requirements. Auxiliary materials: syringe or microinjection device. 2. Steps: (1) Preparation of working solution: prepare a 2% Hydroxystilbamidine solution, which can be sterile filtered. Note: It is recommended to operate in the dark to prevent fluorescence signal attenuation. (2) Injection of dye: Inject the dye into the target nerve or tissue area. Note: Use a microinjector to reduce damage to surrounding tissues. (3) Retrograde transport: After the injection is completed, wait 24-72 hours to allow the dye to be retrogradely transported to the cell body through the nerve endings. (4) Tissue sampling: After the animal is killed, remove the tissue of interest and fix it (usually with 4% PFA). After sectioning, observe under a fluorescence microscope. II. Histochemical staining 1. Material preparation: (1) Hydroxystilbamidine solution (recommended 1-10 μM). (2) Cell or tissue sample. (3) DAPI or other fluorescent contrast dye (optional). 2. Steps: (1) Fixation and permeabilization: (2) Fix cells or tissue with 4% PFA. (3) Permeabilize cell membrane with 0.1-0.5% Triton X-100. 3. Staining: (1) Immerse the sample in Hydroxystilbamidine solution and incubate for 10-30 minutes in the dark. (2) Wash 2-3 times to remove unbound dye. (3) Microscope observation: Use a suitable fluorescence microscope, usually observe fluorescence at 365 nm (UV excitation). Notes: (1) Storage in dark place: Hydroxystilbamidine is susceptible to light degradation. The solution should be stored in dark place. It is recommended to store it at 4℃ for short term and at -20℃ for long term. (2) Operation safety: Avoid direct contact with skin or inhalation. Protective equipment should be worn. (3) Experimental optimization: Adjust the concentration and incubation time according to the sample type and experimental objectives. The above information is based on published literature. Experimental procedures should be appropriately modified to meet specific research demands.
In vivo	Hydroxystilbamidine is an effective suppressor of the plaque-forming cell (PFC) response when given before sheep erythrocytes (SRBC) stimulation. Hydroxystilbamidine depresses the plaque response of the treated mice. Fewer PFC are observed in Hydroxystilbamidine-treated mice throughout the experiment, but the level of suppression decreases with time. By day 14, the number of PFC observed in both the Hydroxystilbamidine treated mice and the control group is essentially at the background level[2].
Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : Insoluble
Keywords	Hydroxystilbamidine
Related Compound Libraries	Bioactive Compound Library \| ReFRAME Related Library \| Inhibitor Library \| Bioactive Compounds Library Max \| Human Metabolite Library

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