| Name | Hypaconitine |
| Description | Hypaconitine, an active and highly toxic constituent derived from Aconitum species, possesses anti-inflammatory activity and is widely used to treat rheumatism. |
| Animal Research | Adult Wistar rats were orally administered?Hypaconitine?(0.23, 0.69, 2.07 mg/kg per day), liquiritin (20 mg/kg per day), or?Hypaconitine?(2.07 mg/kg per day) plus liquiritin (20 mg/kg per day) for seven consecutive days. The mRNA expression levels of CaM and Cx43 in rat myocardial tissue were determined by real-time quantitative PCR. The protein contents of CaM and phosphorylated Cx43 (Ser368) were determined by Western blot |
| In vitro | Hypaconitine (0.08-2 microM) depressed the nerve-evoked twitch tension, without affecting the contraction evoked by stimulation of the muscle,At the concentrations of hypaconitine (up to 5 microM)that depressed the nerve-evoked twitch tension, the resting membrane potential of the muscle cells was unchanged. Hypaconitine (0.1-2 microM) blocked the end-plate potential (epp), without affecting the amplitude of the miniature epp (mepp). The quantal content of end-plate potentials was decreased by these agents in parallel with the decrement in amplitude. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.25 mM), Sonication is recommended.
DMSO : 50 mg/mL (81.21 mM), Sonication is recommended.
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| Keywords | Tumor Necrosis Factor Receptor | TNFR | TNF Receptor | Inhibitor | inhibit | Hypaconitine | CYP17 |
| Inhibitors Related | Kaolin | 2,4,6-Tri-tert-butylphenol | Gum arabic | Kojic acid | Ipriflavone | 1,8-Cineole | 1,4-Naphthoquinone | Tributyrin | Ethyl linoleate | N,N-Dimethylacetamide | Naringin | Magnesium Chloride Hexahydrate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
