| Name | ICA-27243 |
| Description | ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects. |
| In vitro | ICA-27243 increases both 86Rb+ efflux (EC50 = 0.2 μM) and whole-cell currents in Chinese hamster ovary cells stably expressing heteromultimeric KCNQ2/Q3 channels (EC50 = 0.4 μM). ICA-27243 produces membrane potential hyperpolarization that could be prevented by coadministration with the M-current inhibitors XE-991 and Linopirdine, in SH-SY5Y human neuroblastoma cells [1]. |
| In vivo | In the mouse maximal electroshock epilepsy model, ICA-27243 (1-100 mg/kg; oral administration; male CD-1 mice) has anticonvulsant activity (ED50: 8.4 mg/kg)[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 247 mg/mL (919.41 mM), Sonication is recommended. 10% DMSO+90% Corn Oil : 3.3 mg/mL (12.28 mM), Sonication is recommended.
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| Keywords | PotassiumChannel | Potassium Channel | opener | KcsA | KCNQ3 | KCNQ2/Q3 potassium channel | KCNQ2 | Inhibitor | inhibit | ICA-27243 | ICA27243 | ICA 27243 | hyperpolarization | antiepileptic | anticonvulsant |
| Inhibitors Related | Minoxidil sulfate | Tannic acid | Hydrochlorothiazide | 1,8-Cineole | Tetraethylammonium bromide | Ursodeoxycholic acid | Chenodeoxycholic acid | Minoxidil | Chlorzoxazone | 2,2,2-Trichloroethanol | Taurocholic acid sodium salt hydrate | Indapamide |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | CNS-Penetrant Compound Library | Neuroprotective Compound Library | NO PAINS Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Potassium Channel Targeted Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |