| Name | Ilexgenin A |
| Description | Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr |
| In vitro | Ilexgenin A (IA), a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr.treatment with IA attenuated atherosclerosis in high-fat diet-induced apolipoprotein E deficient mice via a series of effects involving regulation of lipid parameters, decrease of atherosclerosis-related indexes, inhibition of inflammatory cytokines secretion and pathological changes of main organs.?The underlying mechanism of IA was investigated on oxidized low-density lipoprotein (Ox-LDL)-induced THP-1 cells.?Pre-treatment with IA decreased active inflammation cytokines involving interleukin-6 (IL-6), IL-1 and tumor necrosis factor-α (TNF-α) expression in a concentration-dependent manner.IA inhibited the phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), IKKα phosphorylation and NF-κB activity induced by Ox-LDL.?Overall, these findings define IA as a novel drug candidate for anti-atherosclerotic therapy[2].
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| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 1 mg/mL (1.99 mM), Sonication is recommended. DMSO : 11 mg/mL (21.88 mM), Sonication is recommended.
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| Keywords | VEGFR | triterpenoid | TNF-α | STAT | ROS | PKC | PI3K | pentacyclic | NO | NF-κB | LDL | Inhibitor | inhibit | inflammation | ILReceptor | Ilexgenin A | Ilex | IL Receptor | IkB | hainanensis | ERK | Caspase | cancer | AMPK | Akt |
| Inhibitors Related | Kaolin | Undecane | Fluorene | Acetylcysteine | Ethyl palmitate | Gum arabic | 1,8-Cineole | Dodecane | 1,4-Naphthoquinone | Tributyrin | Glucosamine | Diallyl disulfide |
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